High CFP score indicates poor prognosis and chemoradiotherapy response in LARC patients

Abstract Background Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis response in locally advanced rectal cancer (LARC) patients. This study aims to explore the prognostic predictive role carcinoembryonic antigen (CEA), Fibrinogen-Albumin Ratio Index (FARI), Prognostic Nutritional (PNI) LARC patients compared them with a novel combined CEA-FARI-PNI (CFP) scoring system. Methods A total 138 undergoing radical surgery following neoadjuvant chemoradiotherapy (NCRT) between January 2012 March 2019 were enrolled. The X-tile program was used determine optimal cut-off values CEA, FARI, PNI, CFP system constructed accordingly. ability these factors assessed by time-dependent receiver operating characteristic (ROC) curve, Kaplan–Meier, Cox regression, logistic regression. Nomogram established evaluate response. Results PNI 5.15 ng/l, 10.56%, 42.25 g/L, respectively. ROC curve showed that stable efficacy for overall survival (OS) disease-free (DFS). In multivariate analysis, only factor could independently predict OS (HR = 8.117, p 0.001) DFS 4.994, < 0.001). Moreover, high (OR 3.693, 0.002) also an independent risk poor area under (AUC) nomograms predicting better including (0.717) than without (0.656) (p 0.05). Conclusions score more reliable marker OS, DFS, NCRT patients, apparently improve predicted nomogram.